ACCS Practice Exam 2026 – Complete Test Preparation Guide

Naloxone is a medication specifically designed to reverse the effects of opioid overdose. It works as an opioid antagonist, meaning it binds to the same receptors in the brain that opioids do, effectively displacing the opioids and reversing their depressant effects, especially on the respiratory system. This is crucial in cases of overdose when respiratory depression can lead to hypoxia and potentially result in death.

Naloxone can be administered via various routes, including intranasally and intramuscularly, making it accessible for emergency situations. The quick onset of action makes it an essential tool in emergency medicine and community settings where opioid overdoses are a growing concern.

The other options listed, while important medications in their own right, do not reverse the effects of opioids. Flumazenil, for example, is a benzodiazepine antagonist used in cases of benzodiazepine overdose but does not affect opioids. Atropine is an anticholinergic drug used primarily for bradycardia and certain types of poisoning but is not relevant in opioid toxicity. Digoxin is a cardiac glycoside used for heart conditions and has no role in opioid reversal. Thus, naloxone is the only appropriate choice for reversing opioid overdose.